These are not difficult amps to get good tones out of as versatile as they are. I'm not sure what tone you're after. I've got the 100x combo so the tones may differ slightly. Basically any older type of sound the clean channel or OD1 is the best bet and adjust the gain and EQ accordingly. OD 2 for lots of gain newer sounds. I like OD1 better, it's tighter and punchier whereas OD2 tends to get muddy if the gain is past 6 or 7.