It is counter-intuitive but when running in medium or low power modes, the preamp tube plate voltages are increased due to less power draw on the power tubes. These plate voltage increases are all well within a 12AX7's (ECC83) normal operating range so should not lead to any type of failures. It should increase preamp gain in the lower power modes which may be beneficial to players looking for more dirt at lower volumes, though it will be of a different quality than power amp distortion.The powerscaling in the Origin 20 doesn't affect the preamp valves, as far as I'm aware, so I don't see a direct connection. Anytime you switch the HT voltages I can image a little spike here and there though. I'd have to check the schematic to confirm that, though.
How about testing the valves one by one? Run through them all in V1, for example. If one sticks out either keep it in there (positive) or throw it away if found to be defective. As @Jethro Rocker and @fitz288 and @speyfly outlined: you really want to narrow this down.