I think there are two reasons amp manufacturers don't recommend this.
1, because you need to "mismatch" your amp and cab impedance and it's confusing for most people.
And 2, you DEFINITELY need to re-bias the amp because the plate voltage will rise if 2 tubes are removed and your tube dissipation will therefore increase. Also, though probably not a major issue, the preamp voltages will be higher than stock even after a re-bias.
1, because you need to "mismatch" your amp and cab impedance and it's confusing for most people.
And 2, you DEFINITELY need to re-bias the amp because the plate voltage will rise if 2 tubes are removed and your tube dissipation will therefore increase. Also, though probably not a major issue, the preamp voltages will be higher than stock even after a re-bias.