The screw holes don't bother me. Interesting that the votes are pretty evenly split, that's pretty much how I feel. I think I will leave it off for a little while but there is something about the "traditional" look with the pickguard on that I like. The black guard with the white layers at the edge helps accentuate the ebony and block inlays.
If it sounds better to you with it off, then by all means take it off.
JMO, but LP's look nakid without pickguards, besides I rest my hand on the PG from time to time.